Jurkat cells were subjected to SDS PAGE followed by western blot with FNab08997(TRIP13 antibody) at dilution of 1:400
IP Result of anti-TRIP13 (IP: FNab08997, 3ug; Detection: FNab08997 1:400) with mouse testis tissue lysate 3000ug.
Immunohistochemistry of paraffin-embedded mouse testis tissue slide using FNab08997 (TRIP13 antibody) at dilution of 1:200
Background
Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double-strand breaks(DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes(By similarity).